Relationship between cerebral cortical microinfarcts, cortical atrophy, and cognition


  • People with cerebral cortical microinfarcts (CMI) exhibit perilesional cortical atrophy in a large area, and global cortical thickness partially mediates CMI-associated cognitive impairment.

Why this matters

  • CMIs have been related to cognitive decline in people with dementia and cerebrovascular disease, but the mechanisms underlying this relationship are not well understood.

  • This study provides evidence that perilesional damage contributes to global cortical atrophy in patients with CMI and provides a better understanding of the impact of CMI on overall brain structure and function.