Relationship between cognitive decline and tau distribution in females


  • Females demonstrate higher levels of tau than males in multiple brain regions which was associated with faster rates of cognitive decline.

Why this matters

  • Females exhibit higher levels of tau pathology, especially in those with apolipoprotein ε4 (APOE4) or with elevated levels of beta amyloid (Aβ).

  • There have been few studies that examine the topographical sex differences in tau distribution across the brain, and none have examined this effect in the context of cognitive decline.