Takeaway
Females demonstrate higher levels of tau than males in multiple brain regions which was associated with faster rates of cognitive decline.
Why this matters
Females exhibit higher levels of tau pathology, especially in those with apolipoprotein ε4 (APOE4) or with elevated levels of beta amyloid (Aβ).
There have been few studies that examine the topographical sex differences in tau distribution across the brain, and none have examined this effect in the context of cognitive decline.