Relationship between genetically determined LDL-C and vascular disease

Takeaway

  • A lifelong increase in genetically determined low-density lipoprotein cholesterol (LDL-C) has a weaker association with ischemic stroke (IS) relative to coronary heart disease (CHD).

Why this matters

  • Management of LDL-C may be more important for prevention and treatment of CHD versus IS, although additional large-scale genetic studies are needed to confirm this.