Relationship between glycemic control and vascular event occurrence in patients with diabetes


  • Pre-stroke glycemic control in patients with diabetes mellitus (DM) influences the risks of composite vascular events and stroke recurrence; the optimal glycated hemoglobin (A1C) is 6.8%–7.0%, dependent on ischemic stroke subtype.

Why this matters

  • It is known that DM increases the risk of both first-ever stroke and recurrent stroke and that poor glucose control is associated with increased risk of cardiovascular (CV) disease; however, evidence is lacking concerning the optimal target A1C to minimize risk of CV events in patients with acute ischemic stroke (AIS).

  • This study provides evidence that glycemic targets should be individualized based on stroke type in order to avoid stroke recurrence.