Relationship between interictal epileptiform discharges and memory encoding

Takeaway

  • Increased interictal epileptiform discharges (IED) rates, IEDs propagating in white matter, and IEDs in the left temporal region had deleterious effects on memory, and increased post-IED alpha power correlated with better memory performance.

Why this matters

    While it is well known that there is an association between cognitive impairment and subclinical IEDs, the relationship of specific IED properties to successful memory has not been well studied. This study provides evidence that examination of IED properties may be useful in improving surgical outcomes and quality of life for people with epilepsy.