Relationship between macula microvascular changes and disability in patients with neuromyelitis optica spectrum disorder


  • The macular microvascular changes in patients with neuromyelitis optica spectrum disorder (NMOSD) may be associated with disability.

Why this matters

  • NMOSD is an autoimmune inflammatory disorder of the central nervous system (CNS) that targets the optic nerve, spinal cord, brainstem, or the brain itself, which results in symptoms such as blindness, paralysis, severe pain, cognitive impairment, and depression. NMOSD may also cause neurodegeneration and astrocyte destruction, leading to severe disability.

  • Optic neuritis (ON) is often the first clinical manifestation in patients with NMOSD, which causes visual impairment. The condition causes inflammation of the retinal microvasculature and serves as an indicator of retinopathy in patients with NMOSD.

  • However, macular microvascular changes in NMOSD are not well-studied, and the relationship between macular changes and disability is unclear.