Relationship between neurofibrillary tangle distribution and clinical heterogeneity in Alzheimer’s disease


  • Age-related variations in distribution of neurofibrillary tangles (NFT) drive clinical and cognitive heterogeneity in Alzheimer’s disease (AD).

Why this matters

  • It has been speculated that differences in distribution of AD pathology may contribute to the age-related clinical heterogeneity.

  • This study supports this hypothesis, particularly concerning variations in NFT, and suggests that age at onset is an important consideration in design and selection of cognitive outcomes measures in AD.