There was no causal relationship between a genetic disposition towards increased serum levels and the risk of developing multiple sclerosis (MS) using Mendelian randomization (MR).
Why this matters
Urate has possible neuroprotective effects in humans. Previous studies have reported low serum urate levels in individuals with MS compared with controls, while other studies have found conflicting results. Therefore, it is important to understand the role of urate in the risk of developing MS.