Relationship between sleep and hippocampal volume in adulthood


  • Worse sleep quality, poorer sleep efficiency, sleep problems, and daytime tiredness are associated with increased hippocampal volume loss over time.

Why this matters

  • The hippocampus is involved in sleep-dependent cognition; increases in sleep disturbances and hippocampal atrophy are both associated with normal aging and Alzheimer’s disease (AD).

  • Understanding the relationship between hippocampal volume and sleep may lead to improvements in clinical diagnosis of AD.