Relationship between TDP-43 and grey matter loss


  • The transactive response DNA-binding protein of 43 kilodaltons (TDP-43) is associated with grey-matter volume loss in people without frontotemporal lobal degeneration (FTLD).

Why this matters

  • In people without FTLD, TDP-43 forms inclusions in a typical pattern; however, this pattern has not been evaluated for its relationship with antemortem grey-matter volume.

  • Understanding the contribution of TDP-43 to aging will help in the development of treatments and clinical trials to improve cognitive outcomes.