Reliability and validity of pupillary response in Parkinson’s disease


  • Pupillary response could be used as a valid and reliable neurophysiological measure of cognitive workload in individuals with Parkinson’s disease (PD).

Why this matters

  • To optimize motor control, performing a dual-task balance might increase the reliance on cognitive resources.

  • Evidence shows that pupillary response reflects cognitive workload (mental effort) in people with PD, but the lack of validity and reliability testing limits its use as a neurophysiological tool.

  • This study demonstrated excellent reliability and validity of pupillary response during dual-task balance in individuals with PD, which is important for predicting people who are at risk of falls and for developing new rehabilitation strategies.