Collaborative International Research in Clinical and Longitudinal Experience Study (CIRCLES) has successfully recruited and retained a large cohort of patients (pts) with neuromyelitis spectrum disorder (NMOSD), and results from this ongoing effort will continue to grow as a repository for clinical data and biological samples in this rare disease.
Why this matters
There is an unmet need for a more detailed understanding of NMOSD etiology, pathogenesis, risk factors, and demographics; research is limited due to rarity of the disease and lack of access to large, well-characterized pt cohorts
This collection of data could allow for rapid advancement of scientific understanding of the disease.
Large number of related controls provides opportunity to study role of familial genotypes and environmental exposures in NMOSD.