Repository of clinical data and biospecimens of patients with neuromyelitis optica spectrum disorder


  • Collaborative International Research in Clinical and Longitudinal Experience Study (CIRCLES) has successfully recruited and retained a large cohort of patients (pts) with neuromyelitis spectrum disorder (NMOSD), and results from this ongoing effort will continue to grow as a repository for clinical data and biological samples in this rare disease.

Why this matters

  • There is an unmet need for a more detailed understanding of NMOSD etiology, pathogenesis, risk factors, and demographics; research is limited due to rarity of the disease and lack of access to large, well-characterized pt cohorts

    • This collection of data could allow for rapid advancement of scientific understanding of the disease.

  • Large number of related controls provides opportunity to study role of familial genotypes and environmental exposures in NMOSD.