Rest-activity functioning in adults at risk of dementia linked to white matter structure


  • There is an intricate relationship between rest-activity rhythms, white matter structure and modifiable risk factors in middle-aged adults at-risk for dementia.

Why this matters

  • Although white matter degeneration and clinical depression are associated with a greater risk of cognitive decline, little is known about the relationship between white matter structure and rest-activity functioning in adults at-risk of dementia.

  • These novel findings suggest that targeting modifiable clinical risk factors, such as high body mass index and depression, could help to improve rest-activity functioning and ultimately reduce the risk of cognitive decline and dementia.