Rest-activity patterns in rapid eye movement sleep behavior disorder

Takeaway

  • Rest-activity pattern alterations, particularly objective napping, activity fragmentation and physical inactivity during active periods are evident at diagnosis of idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) prior to development of α-synucleinopathies, and could serve as robust prodromal markers of conditions with this underlying pathology.

Why this matters

  • iRBD is a putative prodromal feature of α-synucleinopathies including dementia with Lewy bodies and Parkinson’s disease.

  • Identification of robust prodromal markers for α-synucleinopathies could aid understanding of pathophysiology, promote early diagnosis and lead to therapy options for patients with these conditions.