Retinal changes in cerebral amyloid angiopathy

Takeaway

  • Thinning of the retinal nerve fiber layer, detectable by optical coherence tomography (OCT) may be a candidate marker of disease in hereditary cerebral amyloid angiopathy (CAA).

Why this matters ?

  • Dutch-type hereditary cerebral amyloid angiopathy (D-CAA) is a serious, incurable condition leading to intracerebral hemorrhage and vascular dementia; OCT studies have recently provided evidence of potential early marker identification, even in pre-symptomatic cases.

  • Identification of pre-symptomatic disease markers may have a profound impact on the management of people with D-CAA by allowing clinicians to tailor/direct their treatment based on biomarker presence, together with other indicators of disease progression.