Retrospective cohort study of the development of brain metastases in patients with breast cancer


  • Patients with triple negative breast cancer (TNBC) have a higher intracranial tumor burden, which also develops at a higher rate, versus non-TNBC. Although whole brain radiation therapy (WBRT) is standard of care in patients with numerous metastases, it did not offer survival benefits in patients with TNBC.

Why this matters ?

  • Almost half of patients with TNBC develop brain metastases, but there are no extensive studies on the management of brain metastases in TNBC.

  • The findings from this study may influence clinical decision making, as new brain metastases may have developed from the time of initial brain imaging to radiation therapy.