Review and meta-analysis of serum homocysteine, pyridoxine, folate, and vitamin B12 in migraine


  • People with migraine have higher serum homocysteine (Hcy) concentration, lower levels of serum folate, and similar levels of vitamin B12 compared with healthy controls.

Why this matters

    This is the first meta-analysis to investigate Hcy concentration in people with migraine and may increase our understanding of the association between elevated serum Hcy and migraine and inform vitamin supplementation practices.