Risk assessment in carriers of both GBA and LRRK2 mutations for Parkinson’s disease

Takeaway

  • Ashkenazi Jewish (AJ) patients carrying glucocerebrosidase (GBA) variants are more susceptible to Parkinson’s disease (PD) with higher prevalence of non-motor features compared to patients carrying a single mutation of leucine-rich repeat kinase 2 (LRRK2) or both.

Why this matters

    Clinical genetic analysis of GBA and LRRK2 variants could help determine the genetic susceptibility to PD in the AJ population.