Risk of onset of clinical symptoms following diagnosis of Radiologic Isolated Syndrome


  • Baseline demographic, clinical and imaging metrics can be used to predict the likelihood of developing clinical symptoms within 10 years of a Radiologically Isolated Syndrome (RIS) diagnosis. In particular, those who were younger at the time of diagnosis, those with positive cerebrospinal fluid findings and the presence of infratentorial/spinal cord lesions were associated with an increased risk of a clinical event.

Why this matters

    RIS was defined in 2009 to describe individuals with imaging findings that were similar to patients with multiple sclerosis, but were identified incidentally. Approximately half of the subjects in this study experienced a clinical event within 10 years of diagnosis. Identification of independent predictors of risk for symptom onset may aid in the clinical management of individuals with RIS, allowing early MS treatment and improved clinical outcomes.