Role for angiotensin-converting enzyme-overexpressing macrophages in Alzheimer’s disease


  • Angiotensin-converting enzyme (ACE) may play a neuroprotective role in Alzheimer’s disease.

Why this matters

  • Angiotensin-converting enzyme (ACE) is known to degrade amyloid-beta protein.

  • Alzheimer’s disease (AD) is characterized by the accumulation of amyloid plaques in the brain through a neuroinflammatory response.

  • A better understanding of this neuroinflammatory response could lead to the development of novel immunotherapies that destroy the amyloid accumulation and support tissue healing and cognition in people with AD.