Role of miR-603 micro-RNA in acquired radiation resistance in glioblastoma

Takeaway

  • Extracellular vesicle export of miR-603 micro-RNA (miRNA) in glioblastoma is induced by radiation treatment, which subsequently promotes the cancer stem cell state and up-regulates DNA repair, promoting acquired radiation resistance.

Why this matters

    This study indicates miR-603 as a possible therapeutic target to reduce radiation-acquired resistance in glioblastomas, the most common brain cancer in adults.