Safety analysis of stem cell transplantation in amyotrophic lateral sclerosis


  • Injection of bone marrow mononuclear cells (BMMCs) into the tibialis anterior (TA) muscle of people with amyotrophic lateral sclerosis (ALS) has a favorable safety profile and results in an increased D50 index versus control muscle.

Why this matters

  • Stem cell transplantation could represent a promising new therapeutic approach for people with ALS, for whom there is currently no curative treatment.  

  • The D50 index might be the most sensitive parameter for detecting subtle changes in motor units (MU) and differences in ALS progression, which should be considered in future studies.