Scalp ripples predict epilepsy development in children after an initial unprovoked seizure

Takeaway

  • Compared with spikes and spike ripples, scalp ripples were the best predictor of epilepsy development and the risk of future seizures in children following their first unprovoked seizure.

Why this matters

    Interictal spikes are the main biomarker used to predict the risk of epilepsy and future seizures, however, interictal epileptic activity is not reliably correlated to seizure activity and lacks both sensitivity and specificity. Scalp high frequency oscillations (HFOs) have been associated with disease severity but have not yet been analyzed as a predictive biomarker in children following their first unprovoked seizure.