Screening the eyes for cognitive impairment in multiple sclerosis


  • Cognitive impairment could potentially be screened for in people with multiple sclerosis (MS) using optical coherence tomography (OCT) to measure retinal layer thickness (RLT), identifying high-risk patients for further neuropsychological testing.

Why this matters

  • Cognitive impairment can be a significant feature of MS, even for people with early-stage disease. It is difficult to identify early, with regular neuropsychological monitoring for cognitive impairment not well integrated into the current model of care.

  • Measuring RLT using OCT is an inexpensive and feasible tool that has been used in MS to measure neurodegeneration. It is possible RLT could be a biomarker of cognitive impairment.