Sensitivity and specificity of diffusion tractography in glioma


  • Pre-operative magnetic resonance imaging (MRI)-based diffusion tractography was able to accurately predict the spatial location of brain tracts in patients with glioma.

Why this matters

  • MRI-based diffusion tractography is a neurosurgical approach used to estimate fiber tracts ­in vivo. This facilitates pre-operative examination of how brain tumors have caused displacement, infiltration, or other effects within the brain of an individual patient.

  • Awake craniotomy is not feasible in all patients, meaning intra-operative tract monitoring is not always available. Because of this, there is interest in whether diffusion tractography can also help to predict post-operative functional outcomes and recovery. Greater insight into the specificity and sensitivity of diffusion tractography could help to highlight this potential.