Serologic and genomic techniques to detect enterovirus in brainstem encephalitis

Takeaway

  • Metagenomic next generation sequencing (mNGS) and cerebrospinal fluid (CSF) pan-viral serology (VirScan) enhanced detection of enterovirus versus quantitative reverse transcription polymerase chain reaction (qRT-PCR) in samples from a specific outbreak of pediatric brainstem encephalitis.

Why this matters ?

    These techniques may allow detection and characterization genomic changes that may correlate with modulation of neurovirulence or strain divergence.