Serum cardiac troponin T as a biomarker in amyotrophic lateral sclerosis


  • Serum cardiac troponin T (cTnT) can be a potential marker for patients with amyotrophic lateral sclerosis (ALS) and indicating disease severity over time.

Why this matters

  • ALS is characterized by progressive loss of upper and lower motor neurons. Biomarkers that can guide diagnosis and prognosis in patients with ALS are lacking.

  • cTnT and cardiac troponin I (cTnI) are specifically expressed in cardiac tissue. Increase in their serum levels is a sensitive and specific indicator of acute myocardial injury. A few studies have found that the serum level of cTnT was increased in patients with ALS.