Sex, nosocomial infection, and early death in stroke


  • Female sex was associated with reduced risk of post-stroke mortality within 30 days after adjusting for age and stroke severity, due to a reduced risk of infection and infection-related death. Prevention of post-stroke infections in males could help to reduce the risk.

Why this matters

  • Stroke is a key cause of deaths around the world.  

  • Patient sex is known to be a key factor in stroke epidemiology, presentation, management, and outcomes. However, it is unclear what impact sex has on post-stroke mortality: studies have reported conflicting results and been critiqued over the presence of uncontrolled confounders.

  • It is important to clarify any potential relationship between early post-stroke death and sex, including the causes of death.