Shedding light on cognitive impairment in patients with multiple sclerosis through a multiparametric imaging approach

Takeaway

  • Cognitive impairment in patients with multiple sclerosis (MS) can be explained by structural damage in specific white and gray matter regions more so than resting state functional connectivity.

Why this matters

  • Many patients with MS are affected by cognitive impairment, but the neuroanatomical regions involved in this impairment are not well understood.

  • Active and resting state functional magnetic resonance imaging (MRI) studies have suggested involvement of recruitment and functional connectivity of certain brain regions or networks are involved in causing cognitive impairment, but with conflicting results.