Significant associations between glymphatic function and sleep emphasize the importance of sleep for brain health


  • There is a close relationship between glymphatic function, sleep, and cognition, highlighting sleep as a potential target for dementia prevention and therapeutic agents.

Why this matters

  • The glymphatic system is a fluid-transport pathway that clears cerebral waste products during certain stages of sleep; most research to date has been conducted in animal models with limited human data.

  • This unique study, conducted in community-dwelling older adults, revealed relationships between impaired diffusion tensor imaging-analysis along the perivascular space index, abnormal neuropsychological test performances, and lower gray matter volumes, suggesting that this index could be used as a marker for screening and monitoring cognitive impairment in the elderly.