Skin innervation as a biomarker in Charcot-Marie-Tooth disease type 1A


  • Intraepidermal nerve fiber density, Meissner corpuscle and Merkel cell density are possible outcome measures for nerve damage in people with Charcot-Marie-Tooth disease type 1A (CMT1A).

Why this matters

    New biomarkers are needed to provide objective and reproducible ways to assess nerve damage in people with CMT1A. These findings could help provide additional candidates for outcome measures in future clinical trials.