Sleep duration, sleep quality, and stress associate with hippocampal subfield atrophy


  • Sub-optimal sleep and stress may increase risk of hippocampal subfield atrophy.

Why this matters

  • Reduction in hippocampal volume is often associated with aging, but its causes and mechanisms are poorly understood.

  • Negative associations between hippocampal volume and sleep deprivation have been reported in people with sleep disorders.

  • Chronic stress and raised glucocorticoid levels have also been associated with decreased hippocampal volume and dysfunction.

  • Investigating the effects of sleep and stress on the hippocampus may provide insights into the pathophysiology of age-associated hippocampal atrophy and aid in the development of targeted interventions.