Sub-optimal sleep and stress may increase risk of hippocampal subfield atrophy.
Why this matters
Reduction in hippocampal volume is often associated with aging, but its causes and mechanisms are poorly understood.
Negative associations between hippocampal volume and sleep deprivation have been reported in people with sleep disorders.
Chronic stress and raised glucocorticoid levels have also been associated with decreased hippocampal volume and dysfunction.
Investigating the effects of sleep and stress on the hippocampus may provide insights into the pathophysiology of age-associated hippocampal atrophy and aid in the development of targeted interventions.