Sleep spindles and chronic traumatic brain injury involving white matter regions


  • Sleep spindles are highly resilient to extensive white matter deterioration caused by traumatic brain injury (TBI).

Why this matters

  • Sleep spindles are oscillatory waves occurring during non-rapid eye movement (REM) sleep that are involved in sleep consolidation, learning and memory. Several studies show that sleep spindles interact with and rely on thalamocortical white matter tracts.

  • Individuals who have suffered a TBI often have extensive white matter damage and/or cognitive and functional changes, and could serve as a model of white matter damage to further investigate sleep spindle characteristics.