Small fiber neuropathy is becoming more common and is linked to numerous comorbidities


  • Although small fiber neuropathy is relatively rare, its incidence is rising, particularly in those who are obese; comorbidities such as diabetes and myocardial infarctions are common.

Why this matters

  • Existing population-based data on small fiber neuropathy, characterized by symptoms of pain, is limited, with few studies evaluating longitudinal outcomes, detailed neurological examinations, or the development of large fiber involvement.

  • This important study provides new insights into small fiber neuropathy demographics and disease progression, with the disorder appearing to be increasing in frequency with greater trends towards obesity. Since comorbidities, such as cardiovascular events and diabetes, are common, a multidisciplinary approach to individual care is needed for optimal outcomes.