Smoking may have a role in the development of amyotrophic lateral sclerosis

Takeaway

  • Mendelian randomization (MR) analysis supports previous epidemiological studies suggesting a cause-effect relationship between smoking and risk of developing amyotrophic lateral sclerosis (ALS).

Why this matters

  • Strengthening of the evidence of the linkage between smoking and ALS provokes the need for further research of the biological mechanism of this relationship.