Spasticity and a thin corpus collosum are common in specific forms of hereditary spastic paraplegia

Takeaway

  • The spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia (AP-4-HSP) is characterized by developmental delays in children, alongside microcephaly, spasticity and a thin corpus callosum.

Why this matters

    Children with these characteristics should undergo testing for AP-4-HSP to quickly diagnose or rule out the condition before further progression.