Spatial pain modulation of migraine


  • In adolescents with migraine, the endogenous pain modulatory mechanisms were functional, despite altered ascending nociceptive processing of mechanical stimuli at the neck.

Why this matters

  • Inhibitory pain modulation has been suggested as a contributing pathophysiologic mechanism of migraine and the conditioned pain modulation (CPM) paradigm can be used to assess this mechanism.

  • It was also indicated that the pain sensitivity in people with migraine may differ depending on the anatomical region (local vs non-local relative to the head) where a pressure was applied.