Takeaway
In adolescents with migraine, the endogenous pain modulatory mechanisms were functional, despite altered ascending nociceptive processing of mechanical stimuli at the neck.
Why this matters
Inhibitory pain modulation has been suggested as a contributing pathophysiologic mechanism of migraine and the conditioned pain modulation (CPM) paradigm can be used to assess this mechanism.
It was also indicated that the pain sensitivity in people with migraine may differ depending on the anatomical region (local vs non-local relative to the head) where a pressure was applied.