Stem cell treatment failed to improve functional recovery post ischemic stroke in hypertensive rats

Takeaway

  • Hypertension increased both lesion size and behavioral impairment in an experimental stroke model in rats and administration of human adipose tissue-derived mesenchymal stem cells (hADMSC) failed to result in improvements in lesion size or behavioral recovery. It can thus be suggested that hypertension may reduce treatment success in stroke patients in the clinical setting.

Why this matters

  • Administration of ADMSC has been shown to improve functional recovery and brain repair after a stroke, and proposed as a potential treatment strategy.

  • However, the impact of the comorbidity hypertension on the outcomes of this potential treatment has not previously been examined.