Structural and metabolic changes in frontotemporal dementia

Takeaway

  • This study demonstrated the sensitivity of structural magnetic resonance imaging (MRI) and 18F-fludeoxyglucose positron emission tomography (18FDG-PET) as techniques for monitoring progression in frontotemporal dementia (FTD).

Why this matters

  • Frontotemporal dementia encompasses a group of neurodegenerative diseases characterized by progressive deficits in language, behavior or executive function; brain imaging provides an objective biological measure of disease progression.

  • Structural MRI and 18FDG-PET could potentially be utilized as standard, non–invasive biological measures to track progression of volumetric and metabolic decline in FTD.