Structural networks related to stimulation-induced dysarthria in essential tremor


  • Stimulation-induced dysarthria (SID) in people with essential tremor was associated with motor cortex and cerebellar connectivity, and discriminative fibers that predicted stimulation-induced intelligibility worsening were mapped into a fiber-based atlas structure.

Why this matters

  • Essential tremor, the most common adult movement disorder, can be treated with deep brain stimulation (DBS) but a common serious side effect of this therapy is SID.

  • SID pathogenesis is incompletely understood and there is a great unmet need for therapies that will avoid SID and still effectively maintain tremor control.