Study finds a surprisingly healthy sleep pattern in some patients with amyotrophic lateral sclerosis who are in the completely locked-in state

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Abstract

Persons in the completely locked-in state (CLIS) suffering from amyotrophic lateral sclerosis (ALS) are deprived of many zeitgebers of the circadian rhythm: While cognitively intact, they are completely paralyzed, eyes mostly closed, with artificial ventilation and artificial nutrition, and social communication extremely restricted or absent.

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