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Study points to new subtype of MS based on demyelination pattern

Specialists have identified a subtype of multiple sclerosis (MS) characterized by cortical neuronal loss independent of cerebral white-matter demyelination.

The details were presented in a “Hot Topic” session at ECTRIMS 2018 in Berlin, Germany.

Professor Bruce Trapp of the Lerner Research Institute at the Cleveland Clinic Foundation (Cleveland, Ohio, USA) noted that while demyelination of cerebral white matter is understood to drive neuronal degeneration in MS, recent imaging studies have suggested that demyelination and neuronal degeneration can occur independently.

To investigate further, sections from 97 postmortem MS brains were examined visually. A total of 12 were found to show no evidence of cerebral white-matter demyelination.