Subcortical changes correlate with sensory and motor deficits early in multiple sclerosis progression

Takeaway

  • In patients with multiple sclerosis (MS) and no-to-mild disability, structural changes in subcortical brain structures (thalamus, basal ganglia) correlate with somatosensory and sensorimotor deficiencies.

Why this matters

  • Deficits in sensorimotor integration correlating with subcortical alterations in patients with MS and little disability indicate a need for rehabilitation efforts early in disease progression.