Extent of resection per a combined [18F]-fluoro-ethyl-L-tyrosine positron emission tomography (FET-PET) and magnetic resonance imaging (MRI) approach correlated with improved overall survival in patients with WHO grade III or IV astrocytic glioma. Multi-modal pre-operative imaging could help to improve extent of gross total resection (GTR) during surgery and improve survival outcomes.
Why this matters
Surgical resection is the mainstay of treating WHO grade III or IV gliomas and able to extend both overall and progression-free survival. While complete GTR is impractical given the infiltrative nature of glioma, growing evidence suggests that resection of contrast-enhancing (CE) tumor in early post-operative MRI improves overall survival.
FET-PET can delineate the biological tumor volume and highlight active regions of the tumor, thereby providing additional information to CE MRI to improve assessment of GTR.
A multi-modal approach using CE MRI and FET-PET to examine GTR in grade III and IV glioma could help to improve survival outcomes.