T-cell immunoreceptor expression in the brain in multiple sclerosis and glioblastoma

Takeaway

  • There is higher expression of T-cell immunoreceptor with Ig and ITIM domains (TIGIT) in tumor-infiltrating T cells (TILs) in glioblastoma multiforme than in T-cells from brain lesions in multiple sclerosis (MS).

Why this matters

    This study strengthens the mechanistic rationale that an immunotherapy targeting TIGIT signaling may be a beneficial treatment for glioblastoma multiforme.