Tau and α-synuclein distribution in subtypes of dementia with Lewy bodies

Takeaway

  • Clinical phenotypes of dementia with Lewy bodies (DLB) are associated with the distribution of α-synuclein and tau pathology.

Why this matters

  • Diagnosis of DLB based on neuropathologic features such as α-synuclein is widely established; however, any clinical signatures or patterns associated with DLB subgroups are yet to be established.

  • Identification of clinical phenotypes associated with specific neuropathological patterns in DLB could have potential implications for management of this condition.