Takeaway
Clinical phenotypes of dementia with Lewy bodies (DLB) are associated with the distribution of α-synuclein and tau pathology.
Why this matters
Diagnosis of DLB based on neuropathologic features such as α-synuclein is widely established; however, any clinical signatures or patterns associated with DLB subgroups are yet to be established.
Identification of clinical phenotypes associated with specific neuropathological patterns in DLB could have potential implications for management of this condition.