Tau and cognition – what’s the link?


  • Increased tau in the entorhinal region (ER) is related to poorer global, language, and memory cognition in cognitively normal people.

  • Abnormal tau in the medial temporal lobe is associated with poorer memory function.

Why this matters

  • Establishing specific links between Alzheimer’s pathophysiology and cognitive outcomes can be useful for clinical prognostication and treatment selection.