Tau as a primary cause of neuronal degeneration independent of amyloid-β

Takeaway

  • Pathological tau is a primary cause of dysfunctional plasticity in neuronal networks driving degenerative disease

Why this matters

  • Alzheimer’s disease (AD) and (frontotemporal dementia) FTD are characterized by deposition of hyperphosphorylated tau, a microtubule associated protein, into neurofibrillary tangles in the brain

  • In AD, tau mediates amyloid-β-induced neuronal network dysfunction; however, the role of aberrant tau per se as a driver of network deficits has yet to be properly investigated.