Tau-associated pathology and brain atrophy in Alzheimer’s disease subtypes


  • There is evidence of frontal cortical involvement of tau pathology in behavioral/dysexecutive Alzheimer’s disease (b/d AD).

Why this matters

  • The b/d AD subtype is characterized by predominant behavioral disinhibition, apathy and/or executive dysfunction on cognitive testing, but differential diagnosis remains an issue due to symptom overlap with frontotemporal dementia (FTT); and studies assessing amyloid-β and tau pathology (known AD markers) in b/d AD are scarce.

  • Frontal cortical tau pathology load in b/d AD may potentially be an early diagnostic biomarker for this subtype; diagnostic markers are crucial for earlier and more accurate diagnosis and ultimately, improvements in clinical care and patients’ quality of life.