Tau deposition patterns linked to functional connectivity in Alzheimer’s disease

Takeaway

  • Tau deposition patterns in Alzheimer’s disease (AD) and small vessel disease (SVD) are associated with regions of high functional connectivity in the brain and occur in a temporally hierarchical manner according to disease stage.

Why this matters

  • It is currently unknown whether synchronous neural activity across brain regions is related to the spatial deposition of tau in SVD and across the spectrum of AD severities.